Skip to main content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

The opinions, findings, and conclusions or recommendations expressed are those of the Center author(s) and do not necessarily reflect the views of the National Science Foundation.

Center Overview

The Center for Disruptive Musculoskeletal Innovations (CDMI) represents a novel integration of health care economics, biomedical science, and clinical medicine, researching technologies that will decrease health care costs and improve the management and life of patients with musculoskeletal disease.

CDMI targets the growing burden of musculoskeletal disorders (MSDs) by being a primary source for fundamental research on clinical outcomes and cost, implant materials, tissue engineering, biosensors, implant testing protocols, noninvasive diagnostic and preventive technologies, and novel imaging. Preventing and treating MSDs are of key importance.

Prevention is a priority for U.S. business, as MSDs account for about 37% of all injury cases. The average direct cost of a work-related MSD is more than $32,000. Low-back pain alone is estimated to total in excess of $100 billion annually. Yet the causes of these injuries are not well understood.

Treating MSDs is a critical challenge. MSDs affect more than half of the U.S. adult population, and 75% of those over age 65, imposing an economic burden similar to or even greater than that of coronary heart disease and other major health problems. MSD pain is the main noncancer related reason for opioid use in the U.S. Despite the clear opportunity, federal investment in MSD translational research is disproportionately low.

CDMI will continue to bring physicians, scientists, engineers, and industry partners together to boost collaboration and to train and retain the next generation of scientists and engineers.


  • University of California, San Francisco
  • University of Toledo
  • Ohio State University
View Center Website

Center Personnel

Jeffrey Lotz
Center Staff
+1 415 476 2977

William Marras
Center Staff
+1 614 688 8735

Vijay Goel
Center Staff
+1 419 530 2844

Research Focus

Priority research areas include:

  • Advanced science projects.
  • Biomaterials.
  • Clinical outcomes.
  • Economics.
  • Ergonomics interventions.
  • Innovative technologies and testing.
  • Patient assessment tools.

Within these areas, CDMI is particularly interested in the following kinds of projects:

  • Cross-site validation of computational modeling and simulation.
  • Meta-analysis and development of new test standards, approaches, and test methods.
  • Prediction and prevention of musculoskeletal injury.
  • Prediction and prevention of treatment complications.
  • Understanding the multidimensionality of musculoskeletal pain.


Member Organizations

IUCRC affiliated member organizations are displayed as submitted by the Center. Non-federal organizations are not selected, approved, or otherwise endorsed by the National Science Foundation.