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Center for Bioanalytic Metrology (CBM)

Center Overview

The Center for Bioanalytic Metrology (CBM) advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The CBM has two overarching objectives: to deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new technologies and capabilities across the pharmaceutical, biotechnology, nutrition and agriculture, energy, and analytical instrumentation sectors; and to serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems.

Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, CBM bridges the gap between the initial demonstration of new ideas—the traditional province of academia—and the delivery of practical technologies.

Universities

Purdue University
University of Notre Dame

View Center Website

Center Personnel

Paul Bohn
Center Director
+1 574 631 1849
pbohn@nd.edu

Merlin Bruening
Site Director

mbruenin@nd.edu

Stephen Jacobson
Site Director
+1 812 855 6620
jacobson@iu.edu

Garth Simpson
Site Director
+1 765 496 3054
gsimpson@purdue.edu

Christopher Welch
Center Staff
+1 732 718 5974
chris.welch@icase.center

Corrine Hornbeck
Center Staff
+1 574 631 7385
chornbec@nd.edu

Jessica Schiller
Center Staff
+1 574 631 7923
jschill2@nd.edu

Research Focus

CBM provides its members with research solutions in a variety of areas, including:

Analysis of rare or extremely dilute cells, molecules, exosomes, etc.
Artificial intelligence-driven instrumentation, feedback optimization, and 'driverless' instruments.
Discrimination between large biomolecules and their multimolecule complexes.
Enhanced imaging of cells, organisms, and chemical processes.
Massively parallel approaches to chemical cytometry, genetic profiling, and panel screening.
Online and nearline in situ measurements.
Point-of-use analysis, companion diagnostics, and inexpensive testing in the field.
Reduced volume/materials analysis and experimentation at high throughput and productivity.
Ultrahigh sensitivity assays for trace-level biomarkers and impurities.

Awards

1916691

Phase I IUCRC at Purdue University: Center for Bioanalytic Metrology (CBM)

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff. The CBM is devoted to advancing bioanalytical measurement science and applying these advances to address challenges in small molecule pharmaceuticals or agrochemicals development and delivery, in the analysis of foods, in biologically derived petrochemicals and/or biofuels, and in biological materials analysis. The CBM serves the industrial partners with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and "driverless" instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Purdue University brings specific strength in chemical imaging, mass spectrometry, chromatography, particulate analysis, instrumentation design and development, "big data" analytics, and dimension reduction / machine learning for chemical decision-making. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Read More >

1916645

Phase I IUCRC at Indiana University: Center for Bioanalytic Metrology

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff. The CBM is devoted to tackling important measurement science challenges, broadly defined. Some of our members are primarily interested in bioanalytical measurement science, others in problems relating to small molecule pharmaceuticals or agrochemicals, while still others are primarily interested in the analysis of foods, petrochemicals, or materials. The CBM serves these members with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and driverless instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Indiana University contributes distinct expertise in micro/nanoscale analytical separations and measurement, mass spectrometry and/or ion mobility analysis of gas phase ions, computational analysis of multidimensional data, genomics, proteomics, combinatorial molecular biology for new catalysts and reactions, two-dimensional spectroscopic characterization of biomolecules, electrochemical analysis and imaging, and design and construction of instrumentation and electronics to enable new methods of chemical analysis. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Read More >

1916601

Phase I IUCRC at Notre Dame: Center for Bioanalytic Metrology

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff. The CBM is devoted to advancing bioanalytical measurement science and applying these advances to address challenges in small molecule pharmaceuticals or agrochemicals development and delivery, in the analysis of foods, in biologically derived petrochemicals and/or biofuels, and in biological materials analysis. The CBM serves the industrial partners with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and "driverless" instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Notre Dame contributes distinctive expertise in proteomics and metabolomics, point-of-use diagnostics, multimodal chemical imaging, separations and analyses of complex biofluids, molecular-level characterization of microbial behavior, enhanced vibrational spectroscopies, ion-beam derived materials characterization, and application of nanomaterials and devices to chemical analysis. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Read More >

2412804

IUCRC Phase II Notre Dame: Center for Bioanalytic Metrology (CBM) - Lead Site

The Notre Dame Site of the Center for Bioanalytic Metrology (CBM) works in collaboration with partner Sites at Indiana University-Bloomington and Purdue University to address two objectives: (1) to deliver best-in-class analytic metrology tools and expertise enabling the development of powerful new precompetitive technologies across the pharmaceutical, biotechnology, food/nutrition/agriculture, and energy sectors; and (2) to test applications of new instrumentation to cutting-edge chemical and biochemical problems. These objectives contribute to the national welfare by supporting the development of advanced industrial technologies across all four sectors. In addition, CBM provides compelling opportunities to invigorate human resources through access to hires of Center-trained students and opportunities for continuing education of existing staff. CBM operates under a unified site model, in which projects, independent of location, are associated with any member company with a significant interest in them. In addition, CBM operates by identifying the most timely and important problems of interest to its members and devising projects to address them. This approach is accomplished in a yearly cycle that starts with member companies identifying their most pressing Gaps, Needs, and Opportunities (GNO). These GNOs are used to solicit proposals, and the most timely and responsive proposals are selected for funding. CBM’s research groups projects into five thematic areas - (1) overcoming performance limits, (2) point-of-use technologies, (3) ML/AI data science & automation, (4) chemical imaging, and (5) enabling research technologies. The grouping of project themes recognizes a natural organization of the research carried out within CBM that reflects the strengths of the individual sites, but each theme contains projects of interest to members in all four industry sectors. The Notre Dame site contributes most substantially to the point-of-use technologies and enabling research technologies themes. This mapping reflects the strength of Notre Dame scientists in protein biochemistry, molecular separations, chemical sensors, biomimetic materials, optical spectroscopy, and molecular recognition. CBM research provides longer-term, larger-scale, and more cost-effective solutions to pre-competitive industry measurement science problems than those that can be achieved in-house or through contract research organizations. In addition, CBM provides industry members with compelling opportunities to invigorate human resources through access to hires of Center-trained students and opportunities for continuing education of existing staff. Broader impacts of the CBM include: increasing US economic competitiveness, increasing the number of partnerships between academia and industry, and contributing directly to the development of a globally competitive STEM workforce. This award is co-funded by the following Programs: Industry University Cooperative Research Centers Program in the Division of Engineering Education and Centers - in the Directorate for Engineering, and the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry, Directorate for Mathematical and Physical Sciences. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Read More >

Member Organizations

IUCRC affiliated member organizations are displayed as submitted by the Center. Non-federal organizations are not selected, approved, or otherwise endorsed by the U.S. National Science Foundation.

The opinions, findings, and conclusions or recommendations expressed are those of the Center author(s) and do not necessarily reflect the views of the U.S. National Science Foundation.