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Center for Bioanalytic Metrology (CBM)

Center Overview

The Center for Bioanalytic Metrology (CBM) advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The CBM has two overarching objectives: to deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new technologies and capabilities across the pharmaceutical, biotechnology, nutrition and agriculture, energy, and analytical instrumentation sectors; and to serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems.

Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, CBM bridges the gap between the initial demonstration of new ideas - the traditional province of academia - and the delivery of practical technologies.

Universities

University of Notre Dame
Purdue University
Indiana University

View Center Website

Center Personnel

Paul Bohn
Center Director
+1 574 631 1849
pbohn@nd.edu

Lane Baker
Center Co-Director
+1 812 856 1873
lanbaker@indiana.edu

Garth Simpson
Center Co-Director
+1 765 496 3054
gsimpson@purdue.edu

Christopher Welch
Center Staff
+1 732 718 5974
chris.welch@icase.center

Corrine Hornbeck
Center Staff
+1 574 631 7385
chornbec@nd.edu

Arnie Phifer
Center Staff
+1 574 631 3057
aphifer@nd.edu

Research Focus

CBM provides its members with research solutions in a variety of areas, including:

Analysis of rare or extremely dilute cells, molecules, exosomes, etc.
Artificial intelligence-driven instrumentation, feedback optimization, and 'driverless' instruments.
Discrimination between large biomolecules and their multimolecule complexes.
Enhanced imaging of cells, organisms, and chemical processes.
Massively parallel approaches to chemical cytometry, genetic profiling, and panel screening.
Online and nearline in situ measurements.
Point-of-use analysis, companion diagnostics, and inexpensive testing in the field.
Reduced volume/materials analysis and experimentation at high throughput and productivity.

Ultrahigh sensitivity assays for trace-level biomarkers and impurities.

Awards

1916691

Phase I IUCRC at Purdue University: Center for Bioanalytic Metrology (CBM)

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff.

The CBM is devoted to advancing bioanalytical measurement science and applying these advances to address challenges in small molecule pharmaceuticals or agrochemicals development and delivery, in the analysis of foods, in biologically derived petrochemicals and/or biofuels, and in biological materials analysis. The CBM serves the industrial partners with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and "driverless" instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Purdue University brings specific strength in chemical imaging, mass spectrometry, chromatography, particulate analysis, instrumentation design and development, "big data" analytics, and dimension reduction / machine learning for chemical decision-making.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Read More >

1916645

Phase I IUCRC at Indiana University: Center for Bioanalytic Metrology

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff.

The CBM is devoted to tackling important measurement science challenges, broadly defined. Some of our members are primarily interested in bioanalytical measurement science, others in problems relating to small molecule pharmaceuticals or agrochemicals, while still others are primarily interested in the analysis of foods, petrochemicals, or materials. The CBM serves these members with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and driverless instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Indiana University contributes distinct expertise in micro/nanoscale analytical separations and measurement, mass spectrometry and/or ion mobility analysis of gas phase ions, computational analysis of multidimensional data, genomics, proteomics, combinatorial molecular biology for new catalysts and reactions, two-dimensional spectroscopic characterization of biomolecules, electrochemical analysis and imaging, and design and construction of instrumentation and electronics to enable new methods of chemical analysis.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Read More >

1916601

Phase I IUCRC at Notre Dame: Center for Bioanalytic Metrology

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff.

The CBM is devoted to advancing bioanalytical measurement science and applying these advances to address challenges in small molecule pharmaceuticals or agrochemicals development and delivery, in the analysis of foods, in biologically derived petrochemicals and/or biofuels, and in biological materials analysis. The CBM serves the industrial partners with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and "driverless" instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Notre Dame contributes distinctive expertise in proteomics and metabolomics, point-of-use diagnostics, multimodal chemical imaging, separations and analyses of complex biofluids, molecular-level characterization of microbial behavior, enhanced vibrational spectroscopies, ion-beam derived materials characterization, and application of nanomaterials and devices to chemical analysis.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Read More >

Member Organizations

IUCRC affiliated member organizations are displayed as submitted by the Center. Non-federal organizations are not selected, approved, or otherwise endorsed by the U.S. National Science Foundation.

AbbVie
Agilent Technologies
Corteva
Eli Lilly
Evonik
ExxonMobil
Genentech
Indiana Biosciences Research Institute
Merck
Moderna
Pfizer
Procter & Gamble
Sartorius
Takeda

The opinions, findings, and conclusions or recommendations expressed are those of the Center author(s) and do not necessarily reflect the views of the U.S. National Science Foundation.